Anticholinergic Activity and Schizophrenia
نویسندگان
چکیده
منابع مشابه
Anticholinergic Activity and Schizophrenia.
In this article, we review the downregulation of acetylcholinergic activity in schizophrenia and discuss the similarity and difference between Alzheimer's disease (AD) and schizophrenia in terms of acetylcholine (ACh) and anticholinergic activity (AA); then, we propose the use of cognition-enhancing therapy for schizophrenia. As ACh regulates an inflammatory system, when the cholinergic system ...
متن کاملAnticholinergic Activity and Alzheimer's Disease.
AA cascade in AD’ or ‘progression of AD by its own mechanism’. Although there are AA-inducing factors other than downregulation of ACh (e.g. drugs, febrile illness or mental stress), upregulation of ACh is possible if the ACh system is not depressed or overloaded. Thus, upregulation of the ACh system can inhibit AA even in the presence of other factors ( fig. 1 ). The appearance of AA would the...
متن کاملSerum Anticholinergic Activity as an Index of Anticholinergic Activity Load in Alzheimer's Disease.
We reported a procedure of serum anticholinergic activity (SAA) measurement and the reliability and reproducibility of the receptor binding assay, and we also described the usefulness of SAA measurement reflecting the anticholinergic activity (AA) in the central nervous system (CNS). According to the results of a 10 times repeated measurement of standard atropine binding, the relative error was...
متن کاملAssociation of anticholinergic load with impairment of complex attention and memory in schizophrenia.
OBJECTIVE The authors' goals were 1) to establish a clinically useful standard index of the relative anticholinergic potency of psychiatric medications; 2) to determine which cognitive functions are most affected by the administration of anticholinergic medications to patients with schizophrenia; and 3) to compare in vitro and clinically derived indexes of anticholinergic load in predicting the...
متن کاملInfluence of Antipsychotic and Anticholinergic Loads on Cognitive Functions in Patients with Schizophrenia
Many patients with schizophrenia show cognitive impairment. There is evidence that, beyond a certain dose of antipsychotic medication, the antipsychotic daily dose (ADD) may impair cognitive performance. Parallel to their D2 receptor antagonism, many antipsychotics show a significant binding affinity to cholinergic muscarinic receptors. Pharmacological treatment with a high anticholinergic dail...
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ژورنال
عنوان ژورنال: Neurodegenerative Diseases
سال: 2015
ISSN: 1660-2854,1660-2862
DOI: 10.1159/000381523